Components of supercritical garlic extracts and synthetic unsymmetrical allyl disulfides as prospective antimicrobial agents

2014, №3

сс. 73-82

D.Yu. Zalepugin, N.A. Tilkunova, I.V. Chernyshova, M.I. Vlasov, A.L. Mulyukin

Key words: supercritical extraction, carbon dioxide, garlic, extract, allyl disulfides, biocides

Garlic (Allium sativum L.) extracts, obtained by supercritical CO₂ extraction, are
fractionated into individual components using preparative High Performance Liquid
Chromatography/Gas Chromatography. Several new unsymmetrical allyl disulfides are
synthesized. All obtained synthetic substances and garlic individual components were
tested as potential antimicrobial agents using the following test systems: Candida utilis,
Bacillus cereus, Pseudomonas aurantiaca and Escherichia coli. Synthetic unsymmetrical
allyl disulfides (SUAD) are shown to reveal antimicrobial activity compared to individual
garlic components. Moreover, in some cases they are more effective than widely used
floxacin antibiotics. These results give evidence to consider SUAD as prospective
antibacterial pharmaceutical agents.

Translated article

doi:10.1134/S1990793115070155

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ГОСТ
7.0.100-2018

Залепугин, Д.Ю. Components of supercritical garlic extracts and synthetic unsymmetrical allyl disulfides as prospective antimicrobial agents / Д.Ю. Залепугин, Н.А. Тилькунова, И.В. Чернышова [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2014. – Т. 9. – № 3. – С. 73-82.

TRANSLIT

Zalepugin, D.YU. Komponenty sverhkriticheskih ekstraktov chesnoka i sinteticheskie nesimmetrichnye allildisul'fidy kak potencial'nye antimikrobnye preparaty / D.YU. Zalepugin, M.I. Vlasov, N.A. Til'kunova [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2014. – Т. 9. – № 3. – S. 73-82.

D.Yu. Zalepugin, N.A. Tilkunova, I.V. Chernyshova, M.I. Vlasov, A.L. Mulyukin Components of supercritical garlic extracts and synthetic unsymmetrical allyl disulfides as prospective antimicrobial agents. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 3, 73-82 (2014). https://doi.org/

Components of supercritical garlic extracts and synthetic unsymmetrical allyl disulfides as prospective antimicrobial agents

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